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Image Search Results
Journal: Cancer medicine
Article Title: ADAR1 is a prognostic biomarker and is correlated with immune infiltration in lung adenocarcinoma.
doi: 10.1002/cam4.6044
Figure Lengend Snippet: FIGURE 5 Adenosine deaminase RNA-specific 1 (ADAR1) is involved in immune cell infiltration in lung adenocarcinoma (LUAD) tissue. (A) Multiplex immunohistochemistry staining of LUAD sections of the high- (upper panel) or low- (lower panel) ADAR1 group. (B) Histograms displaying the quantitative data of CD4+, CD68+, CD20+, CD84+, CD86+, and CD206+ cells in the ADAR1-high and ADAR1- low groups. ADAR1+ (magenta), CD4+ T cells (CD4+, green), pan-macrophages (CD68+, yellow), CD8+ T cells (CD8+, red), B cells (CD20+, celeste), myeloid-derived suppressor cells (CD84+, white), M1 macrophages (CD86+, purple), and M2 macrophages (CD206+, orange). (mean ± SD, Student's t-test, ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05, ns p > 0.05, not significant).
Article Snippet: After sequential application of ADAR1 (#81284, Cell Signaling Technology), CD4 (ab183685, Abcam), CD68 (#97778, Cell Signaling Technology) and CD8 (ab237709, Abcam) antibodies or
Techniques: Multiplex Assay, Immunohistochemistry, Staining, Derivative Assay
Journal: Cancer medicine
Article Title: ADAR1 is a prognostic biomarker and is correlated with immune infiltration in lung adenocarcinoma.
doi: 10.1002/cam4.6044
Figure Lengend Snippet: FIGURE 1 Excessive expression of adenosine deaminase RNA-specific 1 (ADAR1) contributes to poor prognosis in non-small cell lung cancer (NSCLC). (A) Representative images of IHC staining with an ADAR1 antibody on lung adenocarcinoma (LUAD) and lung squamous carcinoma (LUSC) tumor tissues and their adjacent normal lung tissues. Scale bars: 200 μm. (B) Proportion of ADAR1high and ADAR1low cases of LUAD or LUSC. (C) ADAR1 mRNA expression levels in NSCLC, LUAD, and LUSC (***p < 0.001). (D) Overall survival curves based on ADAR1 mRNA expression in patients with NSCLC, LUSC, or LUAD.
Article Snippet: After sequential application of
Techniques: Expressing, Immunohistochemistry
Journal: Cancer medicine
Article Title: ADAR1 is a prognostic biomarker and is correlated with immune infiltration in lung adenocarcinoma.
doi: 10.1002/cam4.6044
Figure Lengend Snippet: FIGURE 2 Adenosine deaminase RNA-specific 1 (ADAR1) expression is associated with the clinicopathological characteristics and prognosis of patients with lung adenocarcinoma (LUAD). (A) Analysis of ADAR1 expression levels based on the clinical stages of The Cancer Genome Atlas-LUAD. (B) The expression levels of ADAR1 in stage I, stage II, stage III, stage IV, and normal tissues of patients with LUAD from the present cohort (n = 100). (C) Immunoreactivity score of ADAR1 expression in patients with LUAD at different stages. (D) K-M survival analysis of overall survival for LUAD patients according to the level of ADAR1 protein expression. (E) Univariate and (F) multivariate Cox analyses of ADAR1 in LUAD patients. (***p < 0.001, **p < 0.01, ns p > 0.5 nonsignificant).
Article Snippet: After sequential application of
Techniques: Expressing
Journal: Cancer medicine
Article Title: ADAR1 is a prognostic biomarker and is correlated with immune infiltration in lung adenocarcinoma.
doi: 10.1002/cam4.6044
Figure Lengend Snippet: FIGURE 3 Elevated adenosine deaminase RNA-specific 1 (ADAR1) expression is associated with lymph node metastasis (LNM) in lung adenocarcinoma (LUAD). ADAR1 expression level in LUAD with or without LNM (A) and their immunoreactive scores (B). Scale bars: 100 μm. ADAR1 expression level in primary LUAD or paired LNM lesions (C) and their immunoreactive scores (D). (mean ± SD, Student's t-test, **p < 0.01, *p < 0.05).
Article Snippet: After sequential application of
Techniques: Expressing
Journal: Cancer medicine
Article Title: ADAR1 is a prognostic biomarker and is correlated with immune infiltration in lung adenocarcinoma.
doi: 10.1002/cam4.6044
Figure Lengend Snippet: FIGURE 4 Correlation of adenosine deaminase RNA-specific 1 (ADAR1) with tumor immune infiltration in lung adenocarcinoma (LUAD). Correlation between ADAR1 and 22 tumor-infiltrating immune cells in LUAD samples as analyzed via cell-type identification by estimating relative subsets of known RNA transcripts. An absolute value of |Rho| > 0.1 and p < 0.05 implied that the ADAR1 expression level was significantly associated with the number of immune cells.
Article Snippet: After sequential application of
Techniques: Expressing
Journal: Cancer medicine
Article Title: ADAR1 is a prognostic biomarker and is correlated with immune infiltration in lung adenocarcinoma.
doi: 10.1002/cam4.6044
Figure Lengend Snippet: FIGURE 5 Adenosine deaminase RNA-specific 1 (ADAR1) is involved in immune cell infiltration in lung adenocarcinoma (LUAD) tissue. (A) Multiplex immunohistochemistry staining of LUAD sections of the high- (upper panel) or low- (lower panel) ADAR1 group. (B) Histograms displaying the quantitative data of CD4+, CD68+, CD20+, CD84+, CD86+, and CD206+ cells in the ADAR1-high and ADAR1- low groups. ADAR1+ (magenta), CD4+ T cells (CD4+, green), pan-macrophages (CD68+, yellow), CD8+ T cells (CD8+, red), B cells (CD20+, celeste), myeloid-derived suppressor cells (CD84+, white), M1 macrophages (CD86+, purple), and M2 macrophages (CD206+, orange). (mean ± SD, Student's t-test, ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05, ns p > 0.05, not significant).
Article Snippet: After sequential application of
Techniques: Multiplex Assay, Immunohistochemistry, Staining, Derivative Assay
Journal: Cancer medicine
Article Title: ADAR1 is a prognostic biomarker and is correlated with immune infiltration in lung adenocarcinoma.
doi: 10.1002/cam4.6044
Figure Lengend Snippet: FIGURE 5 Adenosine deaminase RNA-specific 1 (ADAR1) is involved in immune cell infiltration in lung adenocarcinoma (LUAD) tissue. (A) Multiplex immunohistochemistry staining of LUAD sections of the high- (upper panel) or low- (lower panel) ADAR1 group. (B) Histograms displaying the quantitative data of CD4+, CD68+, CD20+, CD84+, CD86+, and CD206+ cells in the ADAR1-high and ADAR1- low groups. ADAR1+ (magenta), CD4+ T cells (CD4+, green), pan-macrophages (CD68+, yellow), CD8+ T cells (CD8+, red), B cells (CD20+, celeste), myeloid-derived suppressor cells (CD84+, white), M1 macrophages (CD86+, purple), and M2 macrophages (CD206+, orange). (mean ± SD, Student's t-test, ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05, ns p > 0.05, not significant).
Article Snippet: After sequential application of ADAR1 (#81284, Cell Signaling Technology), CD4 (ab183685, Abcam),
Techniques: Multiplex Assay, Immunohistochemistry, Staining, Derivative Assay